STATIONARY PHASE, STRESS RESPONSE SIGMA FACTOR FROM MYCOBACTERIUM TUBERCULOSIS, AND REGULATION THEREOF

摘要

sigF is a gene that controls M. tubercolusis latency. A diagnostic test forlatent tuberculosis involves detecting M. tuberculosis sigF in clinicalspecimens. Two genes orfX and orfY regulate sigF expression and sigF activity.M. tuberculosis sigF, orfX and orfY are used in screening methods forpotential therapeutic agents which regulate the growth of M. tuberculosis.