In vitro prognostic test for progressors and non-progressors after hiv infection

摘要

Prognosis of the progression of AIDS in an asymptomatic subject who is seropositive for HIV-1, as well as determining the efficacy of therapeutic treatments of such a subject, is advanced by a prognostic test that entails contacting in vitro the peripheral blood mononuclear cells purified from the subject with interleukin-2 for a period of time sufficient for the IL-2 to stimulate the cells, and then ascertaining and comparing against normal controls the activation status of the thus-treated cells as determined by assaying for cell surface antigen markers. It has been found that this status is predictive of both progression to AIDS and efficacy of treatment.