Controlled release temperature-controlled liposomes coated with N-isopropyl acrylamide / octadecyl acrylate / acrylic acid copolymer and methods for producing the same

摘要

The present invention relates to the preparation of drug release temperature controlled liposomes. The drug release temperature-controlled liposome of the present invention is prepared by adding N-isopropylacrylamide / octadecyl acrylate / acrylic acid copolymer at a weight ratio of 1: 0.05 to 0.2 to a drug-encapsulated liposome suspension, For about 10 to 14 hours to coat the liposome surface with the copolymer. According to the drug release temperature-controlled liposome coated with the N-isopropylacrylamide / octadecyl acrylate / acrylic acid copolymer of the present invention, the content of acrylic acid in the coated N-isopropyl acrylamide / octadecyl acrylate / acrylic acid copolymer , It was possible to linearly control the release temperature of the drug at a temperature of about 28C or higher, preferably about 28-36C, and was more stable at room temperature than conventional heat-sensitive liposomes.