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Assays for factors affecting circularization of DNA, assays for factors affecting DNA integration, factors, and uses thereof
Assays for factors affecting circularization of DNA, assays for factors affecting DNA integration, factors, and uses thereof
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机译:影响DNA环化的因素分析,影响DNA整合的因素分析,因素及其用途
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摘要
An assay for factors that affect integration of DNA into target DNA is disclosed. Assays for methods of screening for factors which effect viral DNA circularization either by homologous recombination, end- to-end ligation, or autointegration, are also disclosed. A method for screening for factors which will enhance circularization rather than integration by testing cellular cytoplasmic fluid under conditions which permit circularization in the fluid is also described. Factors which effect integration and circularization are disclosed. Therapeutic methods for retarding viral infection are also described.
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