Biarilacetilenos inhibitors of matrix metalloprotease,A composition that has Inhibitory activity of matrix metalloprotease and the use of such biarilacetilenos in the manufacture of a Medicament.

摘要

The inhibitory compounds in the matrix, their pharmaceutical components and their use in the production of useful drugs are listed in the table. The compound has formula (I),where R15 is selected from the group consisting of HOCH2, MeOCH2, (n-Pr) 2NCH2, CH3CO2CH2, EtOCO2CH2, HO (CH2) 2, CH3CO2 (CH2) 2, HO2C (CH2) 2, OHC (CH2) 3, HO (CH2) 4, 3-HO-Ph, and PhCH2OCH2; and R16 is selected from formulas (II). These compounds are useful for inhibiting matrix m etaloproteases and, therefore, for combating the disorders to which MMPs contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal diseases, corneal ulcers, poteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, treat us that produce inflammatory responses,Oysters in burns, temporary joint diseases, non biological diseases of nervous system, active metastasis or cartilage degeneration loss after traumatic joint injury, and coronary artery thrombosis after rupture from skin sclerosis.