An isolated polypeptide comprising a portion of an immunogenic Protein of the breast, or a variant of that Protein, a Molecule of a polinucleotidosaislada; expression vector; a cell HuesPED transformed; a Pharmaceutical composition; Vaccine; fusion protein; a method

摘要

An isolated polypeptide comprising a portion of an immunogenic Protein of the breast, or a variant of that Protein, which differs only in changes and / or Conservative substitutions.Where the Protein encoded by deaminou00e1cid os includes a sequence of a polynucleotide Molecule,Which comprises a sequence selected from the group consisting of: (a) nucleotide sequences listed in the SEQ ID no. 1 - 94; (b) the core of the complementosde mencionadassecuencias OTITwo; and (c) sequences that hybridize in a sequence of (a) or (b) in moderadamenteestrictas conditions.Other Objects of the invention are a polinuclu00e9otidos isolated Molecule comprising a sequence of nucleotides that Cod Qualifications polypeptide; AN EXPRESSION vector comprising the Molecule of poLinucleotidos; a host Cell transformed with the expression vector; and a Pharmaceutical composition comprising the polypeptide Vaccine and unportador and acceptable to the fisiologicament INMUNOterapia breast cancer for a fusion protein; polypeptide; a method of diagnosis of breast cancer, a monoclonal antibody that binds to the polypeptide.The anticuerposmonoclonale s are useful in the manufacture of Drugs designed to inhibit the development of breast cancer as well as the methods of diagnosticode breast cancer.Other Objects of the invention are a Diagnostic KIT; peri ir blood cells and antigen-presenting cells.