Etm-305, etm-204, etm-775, substantially pure, processes for treating mammalian leukemia, for treating mammalian lung carcinoma, for treating mammalian colon adenocarcinoma, and for treating mammalian malignant melanoma, pharmaceutical composition, and , process for testing human cytochrome cyp3a4 metabolism of ecteinascidin 743

摘要

"ETM-305, ETM-204, ETM-775, SUBSTANTIALLY PURE, PROCESSES TO TREAT MAMMALIAN LEUKEMIA, TO TREAT MAMMALIAN LUNG CARCINOMA, TO TREAT MAMMALIAN COTONIC ADENOCARCINOMA, MULTIPLE FAMILY, MULTIPLAYER, MULTIPLAYER, MULTIPLAYER, MULTIPLAYER, MULTIPLAYER, MULTIPLE, MULTIPLE, MULTIPLAYER. AND, PROCESS FOR TESTING THE HUMAN CYP3A4 METABOLISM OF CYP3A4 OF ECTEINASCIDINE 743 "The purification and elucidation of the structure of various products of the metabolism of Et 743 by human Cytochrome CYP3A4 were obtained. These compounds are abbreviated here as "ETM" followed by a numerical value that represents the approximate molecular weight. Three compounds have been identified so far, namely ETM 305, ETM 775 and ETM 204. The structures of these ecteinascidin metabolites are shown as ETM 305, ETM 204 and ETM 775.