Control of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) mediated effects to treat chronic inflammatory disorders like atheriosclerosis

摘要

Compounds of formula (1) are described, The compounds of general Formula (1) are useful for the treatment of atherosclerosis and chronic inflammatory disorders; for inhibiting cytokine-induced expression of vascular cell adhesion molecule-1 (VCAM-1) and/or intercellular adhesion molecule-1 (ICAM-1); for inhibiting the peroxidation of LDL lipid; for lowering plasma cholesterol; and as anti-oxidant chemical additives useful for preventing oxidative deterioration in organic materials. Wherein; X is selected from the group consisting (a), (b), (c), (d), (e) or (f); Y is thio, oxy or a methylene group; Z is hydrogen or -C(O)-(CH2)m-Q, wherein Q is hydrogen or -COOH and m is an integer 1, 2, 3 or 4; R1 is C1-C6 alkyl; and R2, R3 and R4 are each independently hydrogen or C1-C6 alkyl.