New human antibiotic peptides, useful for treating microbial infections, particularly when incorporated in wound dressings, also related nucleic acid

摘要

Active, mature protein (I) having a 128 residue SAP-2 amino acid sequence, or a 45 residue SAP-3 amino acid sequence, both fully defined in the specification, or a modified form of SAP-2 or -3 is new. The modified forms are allelic modifications with at least one substitution deletion or insertion, or post-translational modifications, which do not significantly alter the activity. Independent claims are also included for the following: (1) proteins (II) comprising a signal sequence plus the sequence for SAP-2 or -3 (designated Pre-SAP-2 or -3), and comprising 156 and 67 residue amino acid sequences, respectively, both fully defined in the specification and their modified forms; (2) (I) and (II) in which at least one terminus is protected; (3) cDNA or DNA (III) encoding (I) or (II), or their modifications; (4) vector containing (III), a promoter and optionally an enhancer, optionally included in a transformed prokaryotic or eukaryotic cell; (5) a pharmaceutical composition containing at least one of (I) or (II), and a carrier; (6) synthesis of (I) or (II); (7) binding molecules, single-chain proteins and antibodies (or their fragments) that specifically recognize domains in (I); and (8) wound dressing containing at least one (I) or (II), or syngenic or allogenic human cells containing (III).