Medicament for inducing tolerance to antigens, e.g. those causing autoimmune disease, allergy or infections, containing the antigen together with steroid sulfatase inhibitor as adjuvant to improve tolerance induction

摘要

A medicament (A) contains as active component a combination of a steroid sulfatase (SS) inhibitor (I) and an antigen (II). An independent claim is included for a composition comprising (I) and (II). ACTIVITY : Immunosuppressive; antiallergic; antirheumatic; antiarthritic; neuroprotective; ophthalmological; antiinflammatory; antidiabetic; dermatological; antibacterial; virucidal; antifungal; antitubercular. In tolerance tests involving experimental autoimmune encephalitis in rats (an animal model of multiple sclerosis), administration of SS inhibitors (e.g. 1-8 mg of estrone-3-O-sulfamate (Ia) in oil, subcutaneously) before sensitization markedly reduced the amount of antigen (i.e. MBP or MOG) required to produce tolerance (no quantitative results given). MECHANISM OF ACTION : Steroid sulfatase inhibitor; vaccine.