Crystalline forms I and II of (R) - (+) - N - 3 - 1 - Benzoyl - 3 - (3,4-dichlorophenyl) piperidin yl - 1, 3 - prop - yl - 4 - fenilpiperidin - 4-yl - n-methylacetamide (osanetant)Farmaeutica containing Composition and Process for its preparation according to the mixture of solvent and temperature used

摘要

Refers to a process for the preparation of Crystalline forms I and II of (R) - (+) - N - [[3 - [1 - Benzoyl - 3 - (3,4-dichlorophenyl) piperidin yl] - 3 - 4 - phenyl - piperidin-4-yl] - n-methylacetamide (IL osanetant)(i) The osanetant UNAM ezcla is CRYSTALLIZED from ethanol or isopropanol / water to provide formal; (ii) The osanetant is CRYSTALLIZED from a mixture of ethanol / isopropyl ether/ water to give the Crystal II, using different mixes desolventes and temperatures.S and also describe these Crystalline forms I and II of osanetant and a Pharmaceutical composition that comprises.