486 LIVER SPECIFIC BILE ACID DERIVATIVES OF THE GLUCOCORTICOID ANTAGONIST RU486

摘要

(Ⅰ); Novel glucocorticoid receptor ligands of the present invention, the gatneunde the general formula (Ⅰ) Here, R represents a hydrogen atom, an aliphatic hydrocarbon, aromatic hydrocarbon, carboxylic acid or their esters, high-flying hydroxy, halogen, or cyano halogen, or the salts cyano, or a pharmaceutically acceptable. W is a methine carbon atom having the R, S or a racemic (racemic) stereochemistry material. X and Z are the same or different conjugates, an amide (-CONR'- or NR'CO-), an amine (-NR'-), an ether (-O-), or a thioether (-S-) R 'is hydrogen atom, an aliphatic hydrocarbon, or an aromatic hydrocarbon. Symbol n, o are the same or different and is an integer from 1 to 6. m is an integer from 0 to 6. Y is a hydroxy group, a carboxylic acid or their esters, tetrazole, acyl sulfonamide (R "is an aliphatic or aromatic hydrocarbon is -CONHSO ₂ R" or -SO ₂ NHCOR "), or a pharmaceutically acceptable salt thereof a. method for the treatment of diseases that are dependent upon the expression of a disease or a glucocorticoid receptor regulated genes associated with metabolism dysfunction is also provided.