The large-sized animal model of the invasive characteristic lung aspergillus symptom in the immunity defenseless state landlord

摘要

(57) Abstract The model of the systemic characteristic Hyphomycetes /Aspergillus infection in the landlord who is put in deep immunity defenseless state, was established with the beagle dog. The beagle makes immunity control by using the combination of systemic lighting and the everyday steroid, through the bronchial mirror, the time window which the Hyphomycetes can insert successfully is offered. This to localized is converted produces the infection which in one lung leaf, this spreads to pervasion characteristic continuously via the parenchyma cell of the lung, and causes the death of the animal uniformly. This invention furthermore intends the further research of pathological physiology of day harmony body infection Hyphomycetes infection with in vivo, and, the new anti- true germ medicine and offers the example regarding the development of combination of more effective medicine. Lastly, this invention intends the development of technology for early detection of systemic characteristic Hyphomycetes infection.