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HUMANIZED ANTIBODIES, RECOMBINATION VECTORS, TRANSGENIC VECTORS AND METHODS FOR THE PREPARATION OF HUMANIZED ANTIBODIES FROM TRANSGENIC ANIMALS
HUMANIZED ANTIBODIES, RECOMBINATION VECTORS, TRANSGENIC VECTORS AND METHODS FOR THE PREPARATION OF HUMANIZED ANTIBODIES FROM TRANSGENIC ANIMALS
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机译:人源化抗体,重组载体,转基因载体和从转基因动物制备人源化抗体的方法
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摘要
This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more humanized immunoglobulin loci which are capable of undergoing gene rearrangement and gene conversion in the transgenic non-human animals to produce diversified humanized immunoglobulins. The present invention further relates to novel sequences, recombination vectors and transgenic vectors useful for making these transgenic animals. The humanized antibodies of the present invention have minimal immunogenicity to humans and are appropriate for use in the therapeutic treatment of human subjects.
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