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METABOLICALLY ENGINEERING MODIFIED TRUE FUNGI AND METHOD FOR PRODUCING STEROL BY USING THE SAME
METABOLICALLY ENGINEERING MODIFIED TRUE FUNGI AND METHOD FOR PRODUCING STEROL BY USING THE SAME
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机译:代谢工程修饰的真真菌及其制备甾醇的方法
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摘要
PROBLEM TO BE SOLVED: To provide a method for efficiently producing sterols such as zymosterol, cholesta-7,24-dien-3Δ-ol or biosynthetic compound derived therefrom.;SOLUTION: Sterols are separated from a cultured product produced by culturing Eumycetes (yeast or fungi) metabolically engineering modified in a manner to lower the activity of both sterol C-22 desaturase and sterol C-24 methyltransferase and highly express sterol Δ7-reductase and/or sterol Δ5-desaturase.;COPYRIGHT: (C)2004,JPO
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