COMPOUND FOR TREATMENT OF FEMALE SEXUAL DYSFUNCTION CONTAINING AGENT THAT IS CAPABLE OF POTENTIATING cAMP IN SEXUAL GENITALIA HAVING EFFECTS OF ENHANCING ENDOGENOUS cAMP SIGNALING IN FEMALE SEXUAL GENITALIA AND GENITAL BLOOD FLOW WHEREBY RESTORING OR POTENTIATING NORMAL SEXUAL AROUSAL RESPONSE WITHOUT CARDIOVASCULAR SIDE EFFECTS

摘要

PURPOSE: A compound of treating a female suffering from female sexual dysfunction(FSD), in particular FSAD(female sexual arousal disorder) containing an agent that is capable of potentiating cAMP in the sexual genitalia is provided. The method can indirectly or directly enhance endogenous cAMP singling in the sexual genitalia of a female, increase the genital blood flow and enhance vaginal engorgement/lubrication via plasma transudation and clitoral engorgement/sensitivity, whereby restoring or potentiating the normal sexual arousal response without cardiovascular side effects. CONSTITUTION: The treatment of women with FSD or FSAD can be achieved by enhancement of genital blood flow with a vasoactive agent, in which the agent can potentiate cAMP in the sexual genitalia and be admixed with a pharmaceutically acceptable carrier, diluent or excipient. The agent is a mediator for vasodilation of the sexual genitalia of the female(for example, the vagina or the clitoris). The agent can potentiate cAMP in the sexual genitalia, the cAMP is endogenous cAMP. The pharmaceutical composition is applied prior to or during a sexual stimulus.