Monohydrate and Anhydrate of gaboxadol in their Crystalline forms I and II; Preparation procedure; Pharmaceutical Composition and its use for the treatment of Neurological or Psychiatric Disorders., Sleep Disorders, hearing, premenstrual syndrome.

摘要

Gaboxadol Monohydrate in Crystalline form, where the form I has a Spectrum of x-ray Powder diffraction in Values of 20 Cuka used radiation with a Peak at 115; and form II has a Spectrum of x-ray Powder diffraction in 20 Cuka values using radiation with a Peak to 25,2u00ba.The procedure to prepare the way I comprises Dissolving a Salt addition of gaboxadol acids in water; add sufficient basis to provide a pH of approximately 6.5; and collect the resulting precipitate immediately.The procedure to prepare the form II includes Dissolving a Salt addition of gaboxadol acids in water; add sufficient basis to provide a pH of approximately 6.5; The resulting mixture left to Mature for at least 12 hours; and collect the resulting Solid.