AZABENZIMIDAZOLE-BASED COMPOUNDS, METHODS FOR THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION, METHOD FOR MODULATING FUNCTION OF SERINE/THREONINE PROTEIN KINASES WITH AZABENZIMIDAZOLE-BASED COMPOUNDS, METHOD FOR IDENTIFYING COMPOUNDS MODULATING FUNCTIONING OF SERINE/THREONINE PROTEIN KINASE, METHOD FOR PREVENTING AND TREATING SERINE/THREONINE PROTEIN KINASE-RELATED ABNORMAL CONDITIONS WITH AZABENZIMIDAZOLE-BASED COMPOUNDS

摘要

The present invention is directed in part towards methods of modulating the function of serine/threonine protein kinases with azabenzimidazole-based compounds. The methods involve cells that express a serine/threonine protein kinase, such as RAF. In addition, the invention describes methods of preventing and treating serine/threonine protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to azabenzimidazole compounds and pharmaceutical compositions comprising these compounds.