NAFTALENO-UREAS AS POTENTIALS OF GLUCOSE CAPTURE.

摘要

Compound of the formula: ** (Formula) ** characterized in that R1 and R2 are substituents of rings A and are, independently, -SO2NR72, -C (O) NR72, -NR7SO2R7, -NR7C (O) R7, -SO2OR7 , -C (O) OR7, -OSO2R7 or -OC (O) R7; R3 and R4 are independently hydrogen or a C1-C6 alkyl, or R3 and R4 together are - (CH2) 2-, (- (CH2) 3- or (- (CH2) 4-; R5 and R6 are, independently , hydrogen, C1-C20 alkyl, substituted C1-C20 alkyl, cyano, halogen, nitro, -SR8, -C (O) R8, -SO2OR8, -OSO2R8, -SO2NR82, -NR8SO2R8, -OC (O) R8, - C (O) OR8, -C (O) NR82, -NR8C (O) R8, -OR8 or -NR82; each R7 and R8 is independently hydrogen, C1-20 alkyl, substituted C1-C20 alkyl, aryl, aryl substituted, C1-C6 arylalkyl, substituted C1-C6 arylalkyl, C1-C6 heteroarylalkyl, substituted C1-C6 heteroarylalkyl, heterocyclyl, substituted heterocyclyl, heteroaryl or substituted heteroaryl; each Y is independently C1-C20 alkyl, substituted C1-C20 alkyl , cyano, halogen, nitro, -SR,, -OR or -N characterized in that each R is independently hydrogen, C1-C6 alkyl or substituted C1-C6 alkyl; each x is independently 0, 1 or 2; and the linker connects a carbon designated as ca a carbon designated as d, and is: ** (F formula) ** and, where, if R1 and R2 are both -SO2OH, then: (i) neither R5 nor R6 is -SO2OR8 or -OSO2OR8; and (ii) R5 and R6 are not both selected from the group consisting of hydroxyl and hydrogen, unless at least one (Y) x is (Y¿) x, in which x¿ is 1 or 2 and Y¿ it is a halogen, or a pharmaceutically acceptable salt thereof, as a single stereoisomer or a mixture of stereoisomers.