COMPOSITION FOR PREVENTING AND TREATING DIABETES COMPRISING EXTRACT OF RHEUM UNDULATUM WHICH REDUCES INSULIN RESISTANCE BY INCREASING GLUCOSE TRANSPORTERS-4, REDUCES PEPCK ACTIVITY, INHIBITS FORMATION OF GLUCOSE BY INCREASING GLUCOKINASE ACTIVITY AND REDUCES CONCENTRATION OF FREE FATTY ACID AND NEUTRAL FATTY ACID TO DISPLAY EXCELLENT ANTI-DIABETIC ACTIVITY

摘要

PURPOSE: Provided is a composition comprising the extract of Rheum undulatum which reduces insulin resistance by increasing glucose transporters-4, reduces pepck activity, inhibits formation of glucose by increasing glucokinase activity and reduces concentration of free fatty acid and neutral fatty acid to display excellent anti-diabetic activity. Therefore, the composition is useful for preventing and treating diabetes and its complications. CONSTITUTION: The pharmaceutical composition for treating diabetes and its complications is characterized by containing the extract of Rheum undulatum as an active ingredient, pharmaceutically acceptable carrier, diluent, or excipient. The extract is obtained by using water, C1-4 lower alcohol or their mixture as an extracting solvent.