Novel proteins derived from mammals that negatively regulate cell surface expression of antigen presentation-related molecules such as B7-2 molecules or MHC class II molecules and use thereof

摘要

Human c-MIR cloned by the present inventor is a novel protein derived from mammals such as a human homolog having an immunosuppressive function, which is a functionally similar molecule of a viral protein such as K3, K5 protein of Kaposi's sarcoma-associated herpesvirus, As a result of the functional analysis, an immunosuppressive action was observed that suppresses the expression of B7-2 molecule, which is an antigen presentation related molecule, and MHC class II molecules on the cell surface. Therefore, c-MIR is considered to be a factor that regulates the expression of antigen presentation-related molecules in the human immune system by such immunosuppressive action, and development of new immunosuppressive methods, rejection of cells and organs during transplantation It can be used for suppression, treatment of autoimmune diseases, new drug development, etc., and is useful medically and industrially.