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Mutation type APC revelation African clawed frog cultured cell stocks

机译:突变型APC揭示非洲爪蛙培养的细胞原种

摘要

GFP fusion total length and the cell stocks which reveal mutation type APC in stability were obtained making use of the technology which visualizes the protein, in the African clawed frog kidney epithelium cultured cell A6. Making use of this cell, the mutation type APC which C terminal territory deficiency is done discovered the fact that heavily the stratification of the cell is induced. Furthermore, the cell which is stratified heavily with the revelation cell stocks of mutation type APC has kept intercellular bonded structure, the individual (the mouse) you verified that it is the phenomenon which resembles the polyp formation in.
机译:利用使蛋白质可视化的技术,在非洲爪蛙肾上皮培养细胞A6中获得了GFP融合全长和显示出稳定的突变型APC的细胞储备。利用该细胞,完成了C末端区域缺乏的突变型APC发现了诱导细胞大量分层的事实。此外,被突变型APC的揭示细胞原种大量分层的细胞保持了细胞间键合结构,您证实的个体(小鼠)是类似于息肉形成的现象。

著录项

  • 公开/公告号JPWO2004018677A1

    专利类型

  • 公开/公告日2005-12-15

    原文格式PDF

  • 申请/专利权人 エーザイ株式会社;

    申请/专利号JP20040530562

  • 申请日2003-08-19

  • 分类号C12N15/09;C07K14/46;C12N5/10;C12Q1/02;C12Q1/68;G01N33/15;G01N33/50;

  • 国家 JP

  • 入库时间 2022-08-21 21:48:38

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