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Modern blood banking employing improved cell preservation composition

机译:采用改良的细胞保存成分的现代血库

摘要

An improved anticoagulant is based on a higher level of citric acid than is usual (at least about 0.2% weight by volume). The higher citrate is combined with an amino acid as a counterion. The amino acid prevents cellular damage often caused by elevated citrate levels. The amino acid citrate mixture also serves to preserve platelet concentrates and platelet rich plasma during room incubation. Not only does the amino acid citrate combination enhance platelet integrity, it completely inhibits the growth of bacteria such as Staphylococcus epidermidis. Collecting blood of plasma into such higher levels of citrate prevents activation of blood proteins so that fractions made from the blood or plasma have superior characteristics.
机译:改进的抗凝剂是基于比通常更高的柠檬酸水平(至少约0.2%的体积重量)。较高的柠檬酸盐与氨基酸结合作为抗衡离子。氨基酸可防止通常由柠檬酸水平升高引起的细胞损伤。柠檬酸氨基酸混合物还可以在室温下保存血小板浓缩液和富含血小板的血浆。柠檬酸氨基酸组合不仅增强了血小板的完整性,而且还完全抑制了表皮葡萄球菌等细菌的生长。将血浆血液收集到如此高水平的柠檬酸盐中会阻止血液蛋白质的活化,从而使由血液或血浆制成的馏分具有优异的特性。

著录项

  • 公开/公告号US2006019234A1

    专利类型

  • 公开/公告日2006-01-26

    原文格式PDF

  • 申请/专利权人 EDWARD SHANBROM;

    申请/专利号US20040897632

  • 发明设计人 EDWARD SHANBROM;

    申请日2004-07-22

  • 分类号A01N1/02;

  • 国家 US

  • 入库时间 2022-08-21 21:44:33

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