Methods for fabricating derivative of glutamic acid, hydroxy acid derivative of 4 - substituu00ecdo piroglutu00e2mico 4 protected derivative of monatina acid, derived from monatina, derivative of (2R,4R) - monatina, and derived from hydroxy acid - 4 - substituu00ecdo piroglutu00e2mico (2R, 4R) - 4 - protected derivative of acid (2R) - 4 - hidroxipiroglutu00e2mico, compound.Acid derivative of hydroxyl - 4 - substituu00ecdo piroglutu00e2mico 4 - protected, and derived from hydroxy acid - 4 - substituu00ecdo piroglutu00e2mico (2R, 4R) - 4 - protected

摘要

Methods for making derivative of glutamic acid, acid derivative of 1 - hdru00f3xi - 4 - substituu00ecdo piroglutu00e2mico 4 protected derivative of monatina acid, derived from monatina, derivative of (2R,4R) - monatina acid derivative, and hdru00f3xi - 4 - substituu00ecdo piroglutu00e2mico (2R, 4R) - 4protegido, derived from acid (2R) - 4 - hdroxipiroglutu00e2mico, compound.Derivative of acid hdroxil - 4 - substituu00ecdo piroglutu00e2mico 4 - protected, and derived from acid hdru00f3xi - 4substituu00ecdo piroglutu00e2mico (2R, 4R) - 4 - protected ".Process for producing derivative of glutamic acid, represented by monatina,Which comprises a derivative of acid alkylate hidroxipiroglutu00e2mico 4 protected with an alkylation agent to obtain a derivative of 4 - hydroxy acid alquilglutu00e2mico 4 - protected and submit the same to theA hydrolysis and removal of protective group. The derivative of acid hidroxipiroglutu00e2mico 4 protected can be easily produced from hydroxyproline.The derivative of acid hidroxipiroglutu00e2mico 4 protected is selective and estereosseletivamente rented at position - 4 and, after the alkylation, it can easily be converted to a derivative of glutamic acid.It can therefore be used advantageously in particular to produce efficiently monatina possessing a high optical purity.