gene expression profile, methods of identifying wnt pathway modular agents, preparing a gene expression profile, screening a remodeling agent associated with bone loading, and reagents that bind to proteins that modulate bone remodeling and / or bone mineralization, treating a bone mineralization disease or disorder, modulating bone mineralization in a cell and bone mineralization and / or bone remodeling in a patient, and determining whether a compound or composition enhances the loading effect. activity in bone cell activity / function and / or mineralization, candidate agent for treating a low bone mass condition and composition

摘要

"GENE EXPRESSION PROFILE, METHODS FOR IDENTIFYING Wnt PATH MODULATOR AGENTS, PREPARING A GENE EXPRESSION PROFILE, TRIALING AN AGENT THAT ENHANCES BONE LOAD, AND PROBLEM-REAGENT-RELATED REAGENTS BONE AND / OR BONE MINERALIZATION, TREATING A BONE MINERALIZATION DISEASE OR DISORDER, MODULATING BONE MINERALIZATION IN A BONE CELL AND / OR BONE REMODELING IN A PATIOUS OR COMPOSITION BONE LOAD EFFECT ON BONE CELL ACTIVITY / FUNCTION AND / OR MINERALIZATION, CANDIDATE AGENT TO TREAT A LOW BONE MASS CONDITION AND COMPOSITION ". The invention discloses compositions, compounds, apparatuses and methods of using them to study bone mineralization and to identify agents that regulate bone mineralization. Methods of using bone mineralization gene profiles and markings for screening and compound screening are also disclosed. Reagents to modulate bone mineralization are provided for both therapeutic and research use.