2-cyano-pyrrolidine carboxamide compound, method for producing it, medicament, pharmaceutical composition, dpp-iv inhibitor containing such compound, method for treatment and / or prevention of niddm, use of the compound for treatment and / or prevention of niddm and commercial packaging of the pharmaceutical composition containing such compound

摘要

"2-CYANO-PYROLIDINE-CARBOXAMIDE COMPOUND, METHOD FOR PRODUCING IT, MEDICINAL PRODUCT, PHARMACEUTICAL COMPOSITION, DPP-IV INHIBITOR CONTAINING SUCH COMPOUND, METHOD FOR TREATMENT AND / OR PREVENTION OF EIDDM PREVENTION OR USE, OF NIDDM AND COMMERCIAL PACKAGING OF PHARMACEUTICAL COMPOSITION CONTAINING SUCH COMPOUND ". A compound of formula (I) or a pharmaceutically acceptable salt thereof: wherein each x 1 and X 2 is independently lower alkylene; X¬ 3¬ is = CH ~ 2 ~, = CHF or = CF ~ 2 ~; R¬ 1¬ is substituent; R¬ 2¬ and R¬ 3¬ are independently H or lower alkyl; n is 0, 1, 2, 3 or 4! having the activity of inhibiting DPP-IV activity. For this reason they are useful in treating DPP-IV mediated conditions such as NIDDM.