METHOD FOR PRODUCING N-SUBSTITUTED ANILINE DERIVATIVE, 1-SUBSTITUTED INDOLE DERIVATIVE, 1-(1-PYRIDIN-2-YLMETHYL-PIPERIDIN-4-YL)-1H-INDOLE AND 3-(1-METHYL-1H-INDOL-3-YL)-4-1-1-(PYRIDIN-2-YLMETHYL)PIPERIDIN-4-YL-1H-INDOL-3-YL-1H-PYRROLE-2,5-DIONE

摘要

PROBLEM TO BE SOLVED: To provide a method for producing 1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indole as an important intermediate for the production of enzastaurin useful as an anticancer agent in high efficiency and yield at a low cost and provide a method for producing enzastaurin by using the compound.;SOLUTION: The method for producing a 1-substituted indole derivative comprises the reducing amination reaction of an aniline derivative and a carbonyl compound with hydrogen and the subsequent cyclization reaction. The invention further provides methods for producing 1-(1-pyridin-2-ylmethyl-piperidin-4-yl)-1H-indole and enzastaurin by using the 1-substituted indole derivative production method.;COPYRIGHT: (C)2008,JPO&INPIT