method for killing or inactivating microorganisms in mammalian tissue, antimicrobial composition, and method for decolonizing at least a portion of an individual's nasal cavities, anterior nostrils, and / or nasopharynx, for decolonizing at least a portion of an individual's esophageal cavity , to prevent and / or treat an affliction caused or aggravated by a microbial organism in the skin and / or mucosal membrane, to provide residual antimicrobial efficacy on a surface, to prevent and / or to treat an individual for a respiratory distress caused by a microbial infection, to treat a middle ear infection in an individual, to treat chronic sinusitis in an individual, to treat impetigo on an individual's skin, to treat and / or prevent an infection in mammalian tissue, to treat and / or prevent infection of the skin, mucosal tissue, and / or wound of an individual to provide residual antimicrobial efficacy on the skin, mucosal tissue, and / or in an individual's wound and to make an anti

摘要

METHOD TO KILL OR INACTIVATE MICROORGANISM MAMMALIAN TISSUE Node, ANTIMICROBIAN COMPOSITION, AND METHOD TO DECOLONIZE AT LEAST A PORTION OF NASAL CAVINGS, PREVIOUS NARINAS, AND / OR NASOPHYNOSIS FOR AN INDIVIDUAL CAUSES , TO PREVENT AND / OR TREAT AFFECT CAUSED, OR AGGREGATED BY, A MICROBIAN ORGANISM ON SKIN AND / OR MUCOSAL MEMBRANE, TO PROVIDE RESIDUAL ANTIMICROBIAN EFFICACY ON A SURFACE, TO PREVENT AND / OR TREAT A CAUSE A MICROBIAN INFECTION, TO TREAT A MIDDLE EAR INFECTION IN AN INDIVIDUAL, TO TREAT CHRONIC SINUSITIS IN AN INDIVIDUAL, TO TREAT IMPETITION ON AN INDIVIDUAL'S SKIN, TO TREAT AND / OR PREVENT A INFECTION IN THE MATURE OR TISSUE PREVENTING AN INFECTION ON SKIN, MUSCLE TISSUE, AND / OR INJURY OF AN INDIVIDUAL TO PROVIDE RESIDUAL ANTIMICROBIAN EFFICACY ON SKIN, MUCOSAL TISSUE, AND / OR IN A CRATE OF AN INDIVIDUAL AND TO MAKE AN ANTIMICROBIAN COMPOSITION Cationic antiseptic compositions, especially those useful when applied topically, particularly to mucosal tissues (ie, mucosal membranes), including a cationic antiseptic such as as biguanides and bisbiguanides such as chlorhexidine and their various salts including but not limited to salts of diglyconate, diacetate, dimethoesulfate, and dilactate; polymeric quaternary ammonium compounds such as poly (hexamethylene biguanide); silver and various silver complexes; small molecule quaternary ammonium compounds such as benzalkonium chloride and alkyl-substituted derivatives; long chain (C8 -C18) dialkyl quaternary ammonium compounds; cetyl pyridinium halides and derivatives thereof; benzethonium chloride and its alkyl-substituted derivatives; and octenidine. The compositions may also include an enhancer component, a surfactant, a hydrophobic component, and / or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are therefore useful in treating and / or preventing conditions that are caused or aggravated by microorganisms (including viruses).