A COMPOSITION AND A METHOD FOR INDUCING APOTOSIS OF CANCER CELL USING DEK OVEREXPRESSION AND A DROSOPHILA MELANOGASTER OVEREXPRESSING DEK

摘要

An anti-cancer composition containing DEK proteins or nucleic acid coding the DEK proteins is provided to induce apoptosis and inhibit dysplasia of cancer cells by overexpressing DEK to increase caspase-dependent apoptosis. An anti-cancer composition for inducing apoptosis comprises DEK proteins having amino acid sequence of SEQ ID NO:2 or nucleic acid for coding DEK protein having base sequence of SEQ ID NO:1. A transformed drosophila is prepared to overexpress the DEK proteins. The transformed drosophila is obtained by a pUAS-hDEK recombinant vector containing the nucleic acid for coding the DEK proteins. The anti-cancer composition containing the DEK proteins or the nucleic acid coding the DEK proteins is used for treating or preventing cancer.