PROPHYLACTIC OR THERAPEUTIC AGENT FOR RETINAL DISEASES AND METHOD FOR PREVENTING OR TREATING RETINAL DISEASES, EACH COMPRISING JNK (C-JUN N-TERMINAL KINASE)-INHIBITING PEPTIDE, AND USE OF THE PEPTIDE

摘要

The intravitreal administration of a JNK-inhibiting peptide which comprises (a) at least either one of the JNK-inhibiting sequences depicted in SEQ ID NO:1 and SEQ ID NO:2 and (b) at least either one of the transfer sequences depicted in SEQ ID NO:3 and SEQ ID NO:4 and has a length shorter than 150 amino acid residues wherein at least one amino acid residue is a D-amino acid residue can prevent the occurrence of spermidine-induced damage of retinal pigment epitheliums, tunicamycin-induced visual cell injury, and laser-induced choroidal neovascularization. Therefore, the JNK-inhibiting peptide is useful for the prevention or treatment of retinal diseases. By using the JNK-inhibiting peptide, it becomes possible to provide a medicinal agent and a method both of which can prevent or treat retinal diseases through topical administration in eyes. It also becomes possible to provide use of the JNK-inhibiting peptide for the production of the medicinal agent.