THE CONTROLLED RELEASED PHARMACEUTICAL COMPSITIONS OF UDENAFIL FOR SUSTAINED RELEASE PROPERTY

摘要

PURPOSE: A controller release composition for manufacturing sustained release formulation containing udenafil is provided to freely control release time of drug. CONSTITUTION: A controller release composition for manufacturing sustained release formulation contains: udenafil and pharmaceutically acceptable sa a solubility adjusting agent of citric acid, malic acid, adipic acid, ascorbic acid, succinic acid, or tartaric acid; an adsorber of silicon dioxide, calcium silicate, talc, or aluminum magnesium metasilicate; and a hydrophilic polymer of hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethylcellulose, polyethylene oxide, xanthangum, guar gum, locust bean gum, or sodium alginate. The composition additionally contains a pore former, expanding agent, diluting agent, and lubricant.