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Identification of pharmacophores from co-crystals of spleen tyrosine kinase (SYK) and SYK ligands
Identification of pharmacophores from co-crystals of spleen tyrosine kinase (SYK) and SYK ligands
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机译:从脾酪氨酸激酶(SYK)和SYK配体的共晶体鉴定药效团
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摘要
The invention comprises for methods of identifying pharmacophores based on the spleen tyrosine kinase (SYK) protein or fragment thereof. The invention further provides methods of identifying SYK inhibitors using pharmacophores that are identified from co-crystals of SYK and its ligands. Further, the invention comprises methods of inhibiting SYK comprising contacting the residues lining the binding site with an inhibitor compound identified from pharmacophores.
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