ANTI-OBESE EFFECT OF POLY HERBAL EXTRACT IN HIGH FAT DIET FED OBESE MOUSE

摘要

The Poly herbal formulation comprised ten different potent herbs from Indian System of Medicine (ISM). Herbal formulation is prepared by mixing all crude dry powder into 1:1 ratio followed by ethanol extraction and freeze drying. The anti-obese potential of the formulation is tested in-vitro LDL oxidation test, the herbal syrup at the concentration of µg - 100µ significantly reduced the low density lipoprotein oxidation with and without BSA. In in-vivo test, obesity is induced by standard high fat diet fed C57BL6 mice. The herbal formulation at the dose of 100 and 200 mg/kg given orally for 20 days significantly decrease the body weight, total cholesterol, triglycerides, low density lipoprotein (LDL) profile levels in high fat diet fed obese mice. Further it affects with few hemodynamic parameters like Bleeding time (BT), Prothrombin time (PT), and Clotting time (CT).