ACTINOMYCES PYOGENES AND ACTINOMYCES PYOGENES/FUSOBACTERIUM NECROPHORUM VACCINES FOR IMMUNIZING CATTLE AND SHEEP

摘要

Novel inocula for administration to ruminant animals such as cattle or sheepare provided in order to immunize the animals and lessenthe incidence of liver abscesses and/or foot rot therein. In one aspect, theinvention pertains to an A. pyogenes-derived vaccine includingan inactivated cell culture product (e.g., cell-elaborated supernatant) fromA. pyogenes cell culture in a suitable carrier. In another aspect,the invention relates to a multivalent vaccine including at least first andsecond bacterial components in a carrier, the first componentcomprises an inactivated cell culture product of A. pyogenes whereas thesecond component comprises an inactivated cell culture product ofF. necrophorum. The inocula of the present invention finds particular utilityin incidences where ruminant animals are particularly subjectto A. pyogenes infection leading to liver abscesses and/or foot rot, e.g.,where the animals are regularly treated with an antibiotic or wherecattle are fed a high grain content concentrate diet.