PEPTIDE LanA1, EXTRACTED FROM Bacterium bacillus LICHENIFORMIS VK21, HAVING ANTIMICROBIAL EFFECT

摘要

FIELD: medicine.;SUBSTANCE: biologically active peptide is proposed with the common formula: , where OBu - residue of 2-oxobutyric acid, Abu - residue of 2-aminobutyric acid, Dha - residue of 2,3-didehydroalanine, Dhb - residue of 2,3-didehydroaminobutyric acid, besides residues are in sequence linked with amide links, residues Abu³-Ala⁷, Abu²²-Ala²⁷ and Abu²⁴-Ala³¹ are also linked pairwise with thioether links with formation of three residues of 3-methyllanthionine, residues Ala¹¹-Ala²¹ are linked with thioether link to form residue of lanthionine. This peptide has antimicrobial effect at gram-positive bacteria Bacillus subtilis, strains L1 and 1621; Bacillus pumilus, strain 2001; Bacillus globigii, strain I; Bacillus amyloliquefaciens, strain I; Bacillus megaterium, strain VKM41; Mycobacterium smegmatis, strain 1171; Mycobacterium phlei, strain 1291; Micrococcus luteus, strain B 1314; Staphylococcus aureus, strain 209p; Rhodococcus sp., strain SSI.;EFFECT: increased efficiency of peptide antimicrobial action.;4 dwg, 1 tbl, 6 ex