METHOD OF TREATING TERM AND NEAR-TERM NEONATE HAVING HYPOXIC RESPIRATORY FAILURE ASSOCIATED WITH CLINICAL OR ECHOCARDIOGRAPHIC EVIDENCE OF PULMONARY HYPERTENSION

摘要

PROBLEM TO BE SOLVED: To evaluate and possibly exclude from treatment patients eligible for treatment with iNO, who have pre-existing left ventricular dysfunction (LVD).SOLUTION: A method of treating a term and near-term neonate having hypoxic respiratory failure associated with a clinical or echocardiographic evidence of pulmonary hypertension includes: (a) providing pharmaceutically acceptable nitric oxide gas to a medical provider; and (b) informing the medical provider that excluding the patients who have pre-existing LVD from the treatment reduces the risk or prevents the occurrence of the adverse event or serious adverse event associated with a medical treatment. The left ventricular afterload may be minimized or reduced by administering a pharmaceutical dosage form comprising nitroglycerin or calcium channel blocker to the patient. The left ventricular afterload may also be minimized or reduced using an intra-aortic balloon pump.