首页> 外国专利> CALCIUM SENSOR STIM1 AND THE PLATELET SOC CHANNEL ORAI1 (CRACM1) ARE ESSENTIAL FOR PATHOLOGICAL THROMBUS FORMATION

CALCIUM SENSOR STIM1 AND THE PLATELET SOC CHANNEL ORAI1 (CRACM1) ARE ESSENTIAL FOR PATHOLOGICAL THROMBUS FORMATION

机译：钙传感器STIM1和血小板SOC通道ORAI1（CRACM1）对于病理性血栓形成至关重要

页面导航

摘要
著录项
相似文献

摘要

The present invention relates to a pharmaceutical composition comprising an inhibitor of stromal interaction molecule 1 (STIM1) or an inhibitor of STIM1-regulated plasma membrane calcium channel activity, in particular an inhibitor of Orai1 (also designated as CRACM1), and optionally a pharmaceutically active carrier, excipient or diluent. The invention further relates to an inhibitor of stromal interaction molecule 1 (STIM1) or an inhibitor of STIM1-regulated plasma membrane calcium channel activity, in particular an inhibitor of Orai1 (also designated as CRACM1), for treating and/or preventing a disorder related to venous or arterial thrombus formation.

机译：本发明涉及药物组合物，其包含基质相互作用分子1（STIM1）的抑制剂或STIM1调节的质膜钙通道活性的抑制剂，特别是Orai1的抑制剂（也称为CRACM1），以及任选地药物活性剂。载体，赋形剂或稀释剂。本发明进一步涉及基质相互作用分子1（STIM1）的抑制剂或STIM1调节的质膜钙通道活性的抑制剂，特别是Orai 1 的抑制剂（也称为CRACM1），用于治疗和/或预防与静脉或动脉血栓形成有关的疾病。 展开▼

著录项

公开/公告号US2011305709A1

专利类型

公开/公告日2011-12-15

原文格式PDF

申请/专利权人 ATTILA BRAUN;CHRISTOPH KLEINSCHNITZ;BERNHARD NIESWANDT;GUIDO STOLL;DÁVID VARGA-SZABÓ;
展开▼

申请/专利号US20090933191

发明设计人 ATTILA BRAUN;CHRISTOPH KLEINSCHNITZ;BERNHARD NIESWANDT;GUIDO STOLL;DÁVID VARGA-SZABÓ;
展开▼

申请日2009-03-20

分类号A61K39/395;A61K31/7088;A61P7/02;C12Q1/02;A61P9/10;A61K31/713;A61K31/616;

国家 US

入库时间 2022-08-21 17:32:07

相似文献

专利

外文文献

中文文献

1. Calcium sensor STIM1 and platelet SOC channel Orai1 (CRACM1) essential for pathological thrombus formation [P] . 日本专利： JP2011515376A . 2011-05-19

机译：钙传感器STIM1和血小板SOC通道Orai1（CRACM1）对于病理性血栓形成至关重要

2. THE CALCIUM SENSOR STIM1 AND THE PLATELET SOC CHANNEL ORAI1 (CRACM1) ARE ESSENTIAL FOR PATHOLOGICAL THROMBUS FORMATION [P] . 韩国专利： KR20100129319A . 2010-12-08

机译：钙传感器STIM1和血小板SOC通道ORAI1（CRACM1）对于病理性血栓形成至关重要

3. The calcium sensor STIM1 and the platelet SOC channel Orai1 (CRACM1) are essential for pathological thrombus formation [P] . 欧洲知识产权局专利： EP2262532A1 . 2010-12-22

机译：钙传感器STIM1和血小板SOC通道Orai1（CRACM1）对于病理性血栓形成至关重要

1. Modulatory effects of the fruits of Tribulus terrestris L. on the function of atopic dermatitis-related calcium channels, Orai1 and TRPV3 [J] . Joo Hyun Nam, Hyo Won Jung, Young-Won Chin, 亚太热带生物医学杂志（英文版） . 2016,第007期

2. Modulatory effects of the fruits of Tribulus terrestris L. on the function of atopic dermatitis-related calcium channels,Orai1 and TRPV3 [J] . Joo Hyun Nam, Hyo Won Jung, Young-Won Chin, 亚太热带生物医学杂志：英文版 . 2016,第007期

3. PLATELET FREE CALCIUM AND SERUM FREE CALCIUM IN ESSENTIAL HYPERTENSION [J] . 陈实, 赵光胜, 李迪元, 上海交通大学学报：医学英文版 . 1990,第002期

4. Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation. [J] . Braun A, Varga-Szabo D, Kleinschnitz C, Blood: The Journal of the American Society of Hematology . 2009,第9期

5. Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation [J] . Karen Gilio, Roger van Kruchten, Attila Braun, The Journal of biological chemistry . 2010,第31期

6. Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor [J] . Xiangyu Cai, Robert M. Nwokonko, Natalia A. Loktionova, The Journal of biological chemistry . 2018,第33期

7. Using CFD to Predict Platelet Activation and Thrombus Formation in a Bioartificial Kidney - (ppt) [C] . S.G. Goebel, A.K. Buck, M.S. Goodin, International Medical Devices Conference . 2019

8. Characterization of the Trafficking of the Store-Operated Calcium Entry (SOCE) Channel ORAI1 Using Quantitative Proteomics [D] . Al-Noubi, Muna Nasser. 2019

9. Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor [O] . Xiangyu Cai, Robert M. Nwokonko, Natalia A. Loktionova, 2018

10. Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation* [O] . Gilio, Karen, van Kruchten, Roger, Braun, Attila, 2010

1. STIM1/ORAI1复合体参与调节人脐静脉内皮细胞SOC和ROC介导的钙内流和NO生成 [J] . 王腊梅 ,胡清华 ,钟华 . 石河子大学学报（自然科学版） . 2017,第003期

2. 基于Stim1/Orai1复合体探索稳心颗粒“调律补心”的钙调控机制 [A] . 郑蕊 . 2016