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Gene polymorphisms as predictors of tumor progression and their use in cancer therapy
Gene polymorphisms as predictors of tumor progression and their use in cancer therapy
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机译:基因多态性可预测肿瘤的进展及其在癌症治疗中的应用
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摘要
The invention provides compositions and methods for determining the likelihood of successful treatment with a pyrimidine based antimetabolite chemotherapy drug and a platinum based chemotherapy drug, such as 5-FU/oxaliplatin. The methods comprise determining the genomic polymorphism present in a predetermined region of a gene of interest and correlating the polymorphism to the predictive response. Patients identified as responsive are then treated with the appropriate therapy.
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