pharmaceutical composition, intravenous infusion bag, vial or ampoule, kit, uses of an hdac inhibitor and one or more cyclodextrin, arginine and meglumine and a composition, and methods of regulating cell proliferation, inhibit cell cycle progression promoting apoptosis, or a combination of one or more of these, in vitro or in vivo, treating an hdac-mediated condition, treating a proliferative condition, and treating cancer

摘要

PHARMACEUTICAL COMPOSITION, Intravenous Infusion Bag, BOTTLE OR BULB, KIT, USES OF A HDAC INHIBITOR AND ONE OR MORE CYCLODEXTRIN, ARGININE AND MEGLUMINE AND A COMPULSION OF THE CULULARULULUL PROULARULAR CULULARULAR PROULAR CULULAR PROMOTE APOPTOSIS, OR A COMBINATION OF ONE OR MORE OF THESE, IN VITRO OR IN VIVO, TO TREAT A HDAC-MEDIATED CONDITION AND TREATMENT OF A PROLIFERATIVE CANCER TREATMENT. This invention relates to pharmaceutical compositions comprising certain carbamic acid compounds (e.g., inhibiting HDAC (histone deacetylase) activity) (e.g. PXD-101, N-hydroxy-3- (3-phenylsulfamoylphenyl) - acrylamide)) and one or more additional ingredients selected from cyclodextrin, arginine and meglumine. The present invention also relates to the use of such compositions, for example, in inhibiting HDAC and treating HDAC-mediated conditions, cancer, proliferative conditions, psoriasis, etc.