首页> 外国专利> METHOD FOR CONSTRUCTING AN ATTENUATED MUTANT STRAIN OF PATHOGENIC BACTERIA, VACCINE, VACCINE VECTOR AND USE OF SAID VACCINE

METHOD FOR CONSTRUCTING AN ATTENUATED MUTANT STRAIN OF PATHOGENIC BACTERIA, VACCINE, VACCINE VECTOR AND USE OF SAID VACCINE

机译：构建致病性细菌，疫苗，疫苗载体的减毒突变株的方法以及所述疫苗的使用

页面导航

摘要
著录项
相似文献

摘要

The present invention discloses a new alternative for preventing salmonellosis, using mutants capable of promoting host immunisation. In particular, these mutants are null for the HU hupA and/or hupB genes, and were tested for virulence attenuation and ability to trigger an effective immune response protecting against salmonellosis, in particular murine salmonellosis, with promising results. In addition, the present invention is aimed at a method for producing this attenuated strain capable of promoting immunisation, at vaccine vectors and vaccines for the treatment of salmonellosis, and at the use thereof for combatting this infection and possibly other diseases, in the case of multifactorial vectors.

机译：本发明公开了使用能促进宿主免疫的突变体预防沙门氏菌病的新方法。特别是，这些突变体对于HU hupA 和/或 hupB 基因无效，并测试了其毒力减弱和触发有效的免疫反应以抵抗沙门氏菌病的能力。特别是鼠沙门氏菌病，具有可喜的结果。另外，本发明的目的是在疫苗载体和用于治疗沙门氏菌病的疫苗上生产能够促进免疫的减毒株的方法，以及在抗击这种感染和可能的其他疾病中的用途。多因子向量。 展开▼

著录项

公开/公告号WO2012142684A1

专利类型

公开/公告日2012-10-26

原文格式PDF

申请/专利权人 UNIVERSIDADE ESTADUAL DE CAMPINAS- UNICAMP;BROCCHI MARCELO;PIVETTA LUCIANE BENEDITA DUARTE;
展开▼

申请/专利号WO2012BR00059

发明设计人 BROCCHI MARCELO;PIVETTA LUCIANE BENEDITA DUARTE;
展开▼

申请日2012-03-07

分类号A61K39/02;A61K39/112;C12N15;C12N15/31;C12N15/73;

国家 WO

入库时间 2022-08-21 17:13:09

相似文献

专利

外文文献

中文文献

1. 用于制备针对因肠致病性细菌引起的感染的广谱疫苗的包含表达内置的多个表位的分子构建体的基本单元的糖缀合物疫苗 [P] . 中国专利： CN106659799B . 2020.07.17

2. 用于制备针对因肠致病性细菌引起的感染的广谱疫苗的包含表达内置的多个表位的分子构建体的基本单元的糖缀合物疫苗 [P] . 中国专利： CN106659799A . 2017-05-10

3. The construction process of lineage attenuated mutant of a pathogenic bacterium, vaccine, vaccine vector and use of the vaccine. [P] . BR132015007038E2 . 2019-01-22

机译：病原菌谱系减毒突变体的构建过程，疫苗，疫苗载体和疫苗的用途。

4. construction process of mutant attenuated lineage of a pathogenic bacterium, vaccine, vaccine vector and use of said vaccine [P] . BRPI1102019A2 . 2013-06-25

机译：病原菌突变体减毒谱系的构建方法，疫苗，疫苗载体及所述疫苗的用途

5. attenuated mutant strain of veterinary infecting bacteria, vaccine for immunization of veterinary species against a bacterial infection, method for immunizing a veterinary species against a bacterial infection and use of an attenuated mutant strain [P] . BRPI0621489A2 . 2011-12-13

机译：兽医感染细菌的减毒突变株，用于针对细菌感染的兽医物种免疫的疫苗，用于针对细菌感染的兽医物种免疫的方法以及减毒突变株的用途

1. Effect of Attenuated Highly Pathogenic Pig Reproductive and Respiratory Syndrome(HP-PRRS) TJM-F92 Strain Vaccine on Immune Antibody Levels against Classical Swine Fever(CSF) and Foot-and-Mouth Disease(FMD) [J] . Luo Zhizhong, Fu Xiandong, Wang Yan 动物与饲料科学：英文版 . 2016,第003期

2. Effect of Attenuated Highly Pathogenic Pig Reproductive and Respiratory Syndrome（HP-PRRS） TJM-F92 Strain Vaccine on Immune Antibody Levels against Classical Swine Fever（CSF） and Foot-and-Mouth Disease（FMD） [J] . Luo Zhizhong, Fu Xiandong, Wang Yan 动物与饲料科学：英文版 . 2016,第003期

3. Evaluating the efficacy of an attenuated Streptococcus equi ssp.zooepidemicus vaccine produced by multi-gene deletion in pathogenicity island SeseCisland_4 [J] . MA Fang, WANG Guang-yu, ZHOU Hong, 农业科学学报（英文版） . 2019,第005期

4. Evaluating the efficacy of an attenuated Streptococcus equi ssp. zooepidemicus vaccine produced by multi-gene deletion in pathogenicity island SeseCisland4 [J] . MA Fang, WANG Guang-yu, ZHOU Hong, 农业科学学报：英文版 . 2019,第005期

5. Induction of deletion mutation onompR gene ofSalmonella enterica serovar Typhi isolates from asymptomatic typhoid carriers to evolve attenuated strains for vaccine development [J] . Senthilkumar B, Anbarasu K, Senbagam D, 亚太热带医药杂志（英文版） . 2014,第012期

6. Level of protection of chickens against highly pathogenic H5 avian influenza virus with Newcastle disease virus based live attenuated vector vaccine depends on homology of H5 sequence between vaccine and challenge virus. [J] . Romer-Oberdorfer A, Veits J, Helferich D, Vaccine . 2008,第19期

7. An attenuated mutant of avian pathogenic Escherichia coli serovar O78: a possible live vaccine strain for prevention of avian colibacillosis [J] . Nagano Tetsuji, Kitahara Rie, Nagai Shinya Microbiology and Immunology . 2012,第9期

8. Poliovirus vaccine strains as mucosal vaccine vectors and their potential use to develop an AIDS vaccine. [J] . Crotty S, Andino R Advanced drug delivery reviews . 2004,第6期

9. PATHOGENICITY OF MLV VACCINE, VACCINE PARENT STRAIN, AND FIELD ISOLATES OF PRRSV [C] . T Opriessnig, PG Halbur, K-J Yoon, Congress of the International Pig Veterinary Society . 2002

10. Generation and characterization of an attenuated mutant in a response-regulator gene of Francisella tularensis live vaccine strain (LVS). [D] . Sammons, Wendy L. 2007

11. Infectivity of attenuated poxvirus vaccine vectors and immunogenicity of a raccoonpox vectored rabies vaccine in the Brazilian Free-tailed bat (Tadarida brasiliensis) [O] . Ben R. Stading, Jorge E. Osorio, Andres Velasco-Villa, -1

12. An attenuated mutant of avian pathogenic Escherichia coli serovar O78: a possible live vaccine strain for prevention of avian colibacillosis [O] . Tetsuji Nagano, Rie Kitahara, Shinya Nagai 2012

13. Identification of Secondary Mutations Which Enhance and Stabilize the Attenuation of Brucella HTRA Mutants: Improving Brucella HTRS-Based Strains as Vaccine [R] . Cardelli, J. A. 2003

1. 表达EtMIC3及EtAMA1蛋白重组减毒鼠伤寒沙门氏菌活载体疫苗株的构建 [C] . 吕俊峰 ,张怡聪 ,李宏梅 . 中国畜牧兽医学会家畜寄生虫学分会第七次代表大会暨第十二次学术研讨会 . 2013

2. 鼠疫亚单位疫苗的制备及其在猕猴中的免疫保护作用评价以减毒伤寒沙门氏菌为载体的鼠疫疫苗构建及初步评价 [A] . 王旺 . 2010