HEPATOCELLULAR CARCINOMA PATHOGENIC RISK ANALYSIS OF CHRONIC B TYPE LIVER DISEASE PATIENT AND THE PREDICTION METHOD THEREOF

摘要

PURPOSE: A hepatocellular carcinoma pathogenic risk analysis of chronic B type liver disease patient and the prediction method thereof are provided to be an important index for controlling the number of routine check for hepatocellular diagnosis.;CONSTITUTION: A hepatocellular carcinoma pathogenic risk analysis of chronic B type liver disease patient and the prediction method thereof comprises the following steps: analyzing onset and non-onset of diseases and the relationship between each mutation on the HBV genes or a combination of mutants between a patient group having the chronic B type liver diseases and a patient group having the hepatocellular carcinoma which is progressed from the chronic B type liver disease; selecting hepatocellular carcinoma prediction markers which show statistical difference between a patient group having the chronic B type liver diseases and a patient group having the hepatocellular carcinoma which is progressed from the chronic B type liver disease by using the relationship between each mutation on the HBV genes or a combination of mutants; deciding mutant combination which is specifically identified in the hepatocellular carcinoma patients among all the possible mutation combinations from the markers for the hepatocellular carcinoma prediction; analyzing genotype of the HBV in the samples collected from the chronic B type liver disease patients; deciding the existence of the mutants of the 8 markers selected from the analyzed genotype; and deciding as a high-risk group of the hepatocellular carcinoma onset in case the combination of markers is applied in the specifically identified mutant combination.;COPYRIGHT KIPO 2013;[Reference numerals] (AA) Number of cases; (BB) Rate of mutant combination patterns related with liver cancer; (CC) Non-HCC having the only BCP mutant; (DD) Liver cancer low risk factor mutant combination pattern; (EE) BCP alternant; (FF) BCP wild type; (GG) Non-HCC not having mutant; (HH) Accumulation number of mutant; (II) 7 liver cancer high risk factor mutant combination pattern