首页> 外国专利> Peptide for augmenting and expression of BDNF and pharmaceutical composition for prevention and treatment of neurodegenerative diseases including Alzheimer's disease or Parkinson's disease, comprising the same

Peptide for augmenting and expression of BDNF and pharmaceutical composition for prevention and treatment of neurodegenerative diseases including Alzheimer's disease or Parkinson's disease, comprising the same

机译:用于增加和表达BDNF的肽以及用于预防和治疗包括阿兹海默氏病或​​帕金森氏病在内的神经退行性疾病的药物组合物,包括该肽

摘要

Disclosed are peptides for augmenting the expression of BDNF (brain-derived neurotrophic factor) and a pharmaceutical composition for the prevention and treatment of Alzheimer's disease or Parkinson's disease, comprising the same. The peptides can induce the expression of BDNF in dopamine-reactive human cells, pass easily through the blood-brain barrier thanks to their low molecular weights and are almost free of cytotoxicity. Thus, they are useful in the prevention and treatment of neuropathies such as Alzheimer's disease or Parkinson's disease.
机译:公开了用于增强BDNF(脑源性神经营养因子)表达的肽和用于预防和治疗阿尔茨海默氏病或​​帕金森氏病的药物组合物,包括该肽。这些肽分子量低,可诱导多巴胺反应性人细胞中BDNF的表达,易于通过血脑屏障,几乎没有细胞毒性。因此,它们可用于预防和治疗神经病,例如阿尔茨海默氏病或​​帕金森氏病。

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