MIXED LINEAGE LEUKEMIA 5 ISOFORM IS A POTENTIAL BIOMARKER AND THERAPEUTIC TARGET FOR HPV-ASSOCIATED CERVICAL CANCER

摘要

A novel isoform of mixed lineage leukemia 5 (MLL5), MLL5β, is described, as is the nucleic acid encoding MLL5β. Methods of inhibiting expression or activity of MLL5β; methods of treating cervical cancer; methods of identifying compounds useful for treating cervical cancer; as well as methods for assessing cervical cells for the presence of cervical cancer and diagnosing cervical cancer, are described. siRNA useful for inhibiting expression of MLL5β are also described.