Lung injury model mouse exposed hyperoxia, and a kit for diagnosis of lung injury model mouse exposed hyperoxia using TAZ marker

摘要

The invention and oxygen exposure lung injury animal model, and TAZ oxygen exposure and using the markers by relates to a diagnostic kit lung injury caused by, TAZ gene-deficient (TAZ ^{- / -} ) mice was induced acute symptomatic pulmonary fibrosis, which is the oxygen-induced lung lungs in mice exposed to the normal group were similar and fibrosis, TAZ is suppressed by the signal molecule acts on the oxidative stress related to the signal path, so the homeostatic regulation of pulmonary function, the TAZ ^{- / -} mice lungs by the oxygen exposure and not only be useful as a fibrosis model mice, and the oxygen concentration of pulmonary fibrosis model mice due to exposure, and using it may be helpful in screening for a candidate therapeutic agent, by confirming the expression of the gene or protein and oxygen TAZ Pulmonary fibrosis can be helpful in diagnosis and diagnostic kit according to the exposure. ;