Methods of reducing cancer cell radiation resistance and proliferation, metastasis and invasion by modulating TM4SF4 expression or activity in non-small cell lung cancer

摘要

The present invention relates to a pharmaceutical composition or anticancer agent for preventing and treating non-small cell lung cancer, comprising a substance that modulates the expression or activity of four-transmembrane L6 family member 4 (TM4SF4). More specifically, the present invention relates to the use of a substance that modulates the expression or activity of TM4SF4 as an anticancer agent or anticancer substance for non-small cell lung cancer. In the present invention, TM4SF4 in adenocarcinoma among non-small cell lung cancer Can reduce the proliferation, metastasis and invasion, and radiation resistance of adenocarcinoma cells by decreasing the expression of TM4SF4 and also increase the expression of TM4SF4 in other non-small cell lung cancers except adenocarcinoma It was confirmed that the proliferation, metastasis and invasion of the cells, and radiation resistance can be reduced. [Selection] Figure 6