SCREENING METHOD FOR CANDIDATE DRUGS FOR HUNTINGTON'S DISEASE USING INDUCED PLURIPOTENT STEM CELLS DERIVED FROM HUNTINGTON'S DISEASE PATIENTS

摘要

The present invention relates to induced pluripotent stem cells derived from Huntington's disease patients (HD-iPSC). In addition, it was verified that when the induced pluripotent stem cells were treated under specific conditions, at a differentiation stage, or differentiated into neurocytes, a Huntington's biomarker is expressed. Through the change of the biomarker, the HD-iPSC is useful in the screening of candidate drugs for Huntington's disease. Further, when genetic defects are removed, the HD-iPSC is useful as an autologous cell therapeutic agent against Huntington's disease.