Salts of 2-amino-1-hydroxy-8-hydroxy-2 (1H) - ona derivatives, competitive activities with muscle receptors and catalytic activities as adrenaline B2 receptors

摘要

1. This list refers to (I) crystal addition salt made of 8-hydroxymethanol-2 (1H) - ona and (II) diacetic acid, sulfuric acid or sulfuric acid or solution acceptable for drugs. Compounds that can be used in respiratory diseases. 1. Characteristic 1: 2-amino-1-hydroxidil-8-hydroximinolin-2 (1H) - one and (I) diacetic acid or sulfuric acid derivatives or acceptable (I) prepared crystallization and medicament salt provided for them, Among them, 2-amino-1-hydroxy-8-hydroxy-2 (1H) - ona derivative has the formula of (1),There: R1,R² and R³ independently represent a hydrogen atom or a C₁₋₂ alkyl group;R⁴ represents a hydrogen atom, a hydroxy group, a hydroxymethyl group or a linear or branched C₁₋₄ alkyl group; R⁵ and R⁶ independently represent a thienyl group, a phenyl group, a benzyl group or a C₄₋₆ cycloalkyl group;V and W are independent of -- N-S - and C (o) groups;The independent value of N and M is 0 to 4.