LIPID BILAYER-INTEGRATED SPP1 CONNECTOR PROTEIN NANOPORE AND SPP1 CONNECTOR PROTEIN VARIANTS FOR USE AS LIPID BILAYER-INTEGRATED NANOPORE

摘要

A conductive channel-containing membrane includes a membrane layer, and a SPP1 connector polypeptide variant that is incorporated into the membrane layer to form an aperture through which conductance can occur when an electrical potential is applied across the membrane. A method of sensing a molecule, such as a polypeptide or nucleic acid molecule, makes use of the conductive channel-containing membrane. A method of DNA sequence makes use of the conductive channel-containing membrane.