RETRO-INVERSO PEPTIDE INHIBITORS OF CELL MIGRATION, EXTRACELLULAR MATRIX AND ENDOTHELIAL INVASION BY TUMOR CELLS

摘要

The present invention discloses retro-inverso peptides and pharmaceutical composition containing them. The peptides of the invention prevent key events occurring during the metastatic process, i.e. invasion of the extracellular matrix, formation of a capillary network, and the entry into bloodstream. They are therefore useful in the treatment of diseases and conditions that are sustained by an increase of cell motility, cell invasion, and/or angiogenesis, such as tumors and chronic inflammation.