首页> 外国专利> METHOD FOR SUPPORTING DIAGNOSIS OF RISK OF COLORECTAL CANCER RECURRENCE, TREATMENT OF COLORECTAL CANCER, AND ADMINISTRATION OF ANTICANCER DRUG

METHOD FOR SUPPORTING DIAGNOSIS OF RISK OF COLORECTAL CANCER RECURRENCE, TREATMENT OF COLORECTAL CANCER, AND ADMINISTRATION OF ANTICANCER DRUG

机译:支持诊断大肠癌复发,大肠癌治疗和抗癌药管理的方法

摘要

Disclosed is a method for supporting a diagnosis of a risk of colorectal cancer recurrence, including the steps of: performing a first measurement to measure the levels of expression of a plurality of genes selected from a first gene group present in a region from 18q21 to 18q23 on the long arm of chromosome 18 in a biological sample collected from a patient with colorectal cancer, a second measurement to measure the levels of expression of a plurality of genes selected from a second gene group present in a region from 20q11 to 20q13 on the long arm of chromosome 20, and a third measurement to measure the levels of expression of a plurality of genes selected from a third gene group including ANGPTL2, AXL, C1R, C1S, CALHM2, CTSK, DCN, EMP3, GREM1, ITGAV, KLHL5, MMP2, RAB34, SELM, SRGAP2P1, and VIM; and determining the risk of colorectal cancer recurrence of the patient based on the levels of expression measured in the measurement step.
机译:公开了一种用于支持诊断大肠癌复发风险的方法,包括以下步骤:进行第一测量以测量选自存在于18q21至18q23区域中的第一基因组的多个基因的表达水平。在从大肠癌患者收集的生物样本中,在第18号染色体的长臂上进行第二次测量,以测量从长在20q11至20q13区域中的第二个基因组中选择的多个基因的表达水平第20号染色体臂,以及第三种测量方法,用于测量选自第三基因组的多个基因的表达水平,包括ANGPTL2,AXL,C1R,C1S,CALHM2,CTSK,DCN,EMP3,GREM1,ITGAV,KLHL5,MMP2 ,RAB34,SELM,SRGAP2P1和VIM;并根据在测量步骤中测量的表达水平确定患者结直肠癌复发的风险。

著录项

  • 公开/公告号US2017073770A1

    专利类型

  • 公开/公告日2017-03-16

    原文格式PDF

  • 申请/专利权人 SYSMEX CORPORATION;

    申请/专利号US201615266385

  • 申请日2016-09-15

  • 分类号C12Q1/68;

  • 国家 US

  • 入库时间 2022-08-21 13:50:42

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